Carnamedica PumpProtect
Clinical Application
PumpProtect® is intended for the flushing and continuous hypothermic machine prefusion (HMP) of organs (kidney and liver) during their storage, transportation, until transplantation, into a recipient, for a period of not more than 24 hours.
PumpProtect®
Exactly formulated to the University of Wisconsin’s UW-MPS (Machine Perfusion Storage) formula, under strict EU CE certification regulations. Considered the Gold Standard in organ preservation, it is a sterile, non-pyrogenic and non-toxic solution for the in-vitro flushing and temporary continuous perfusion preservation of the explanted organs.
PumpProtect® is optimized for hypothermic machine perfusion (HMP) of liver and kidney in providing an extracellular-like solution (high sodium, low potassium), mimicking the blood’s natural plasma to keep the blood vessels relaxed, dilated, and safe for continuous fluid flow. The gold standard in organ preservation, allowing for cold ischemic storage times of up to 20+ hours depending on the organ.
PumpProtect® offers transplant specialists a premium hypothermic MPS preservation solution specifically designed to support medical teams from organ procurement through to transplantation.
PumpProtect® is compatible with a wide range of hypothermic machine perfusion systems.
Preparation & Use
PumpProtect® must be stored in liquid form between +2°C and +25°C, protected from sunlight, cooled before use, and never frozen.
Prior to administration PumpProtect® bags should be cooled to between 2°C and 6°C and visually inspected for clarity and colour.
During organ retrieval, PumpProtect® is administered using standard organ preservation protocols to achieve cooling and continuous machine perfusion of organs.
PumpProtect® should be used by qualified healthcare professionals in accordance with transplant centre protocols. Instructions for Use Links Finally, for MPS storage, the organ must be completely immersed in the solution within its storage container, adhering strictly to the protocols of the transplant center. Donor organs must be flushed free of PumpProtect® prior to transplantation in accordance with the transplant center’s protocols.
Product Specifications
PumpProtect® is a clear to light yellow, sterile, non-pyrogenic solution with an approximate osmolality of 300 mOsm/ kg, potassium concentration of 25 mmol/L and a pH of approximately 7,4 at room temperature.
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Composition |
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Calcium chloride (dihydrate) |
0,068 g |
0,5 mmol/L |
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HEPES (free acid) |
2,38 g |
10 mmol/L |
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Potassium phosphate (monobasic) |
3,4 g |
25 mmol/L |
|
Mannitol (USP) |
5,4 g |
30 mmol/L |
|
Glucose (anhydrous), beta D (+) |
1,80 g |
10 mmol/L |
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Sodium gluconate |
17,45 g |
80 mmol/L |
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Magnesium gluconate (anhydrous) |
1,13 g |
5 mmol/L |
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Ribose, D (-) |
0,75 g |
5 mmol/L |
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Pentafraction (HES) |
50,0 g |
50 g/L |
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Glutathione (reduced form) |
0,92 g |
3 mmol/L |
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Adenine (free base) |
0,68 g |
5 mmol/L |
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Hydroxide |
|
qs pH 7.4 |
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Water for injection |
|
qs 1000 mL |
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Storage Conditions |
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Shelf Life |
18 Months |
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Temperature |
2°C to 25°C, Do not Freeze |
Ordering Information:
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Product Code |
Description |
Presentation |
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PPRT1000 |
PumpProtect® Hypothermic Machine Perfusion (HMP) Organ Preservation Solution 1Ltr.
|
Box / 10 x 1L bags |
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PPRT2000 |
PumpProtect® Hypothermic Machine Perfusion (HMP) Organ Preservation Solution 2Ltr.
|
Box / 5 x 2L bags |
|
SPRT1000 |
StoreProtect® UW Flushing and Cold Static Storage (CSS) organ preservation solution 1Ltr.
|
Box / 10 x 1L bags |
|
SPRT2000 |
StoreProtect® UW Flushing and Cold Static Storage (CSS) organ preservation solution 2Ltr |
Box / 5 x 2L bags |