PumpProtect®

Exactly formulated to the University of Wisconsin’s UW-MPS (Machine Perfusion Storage) formula, under strict EU CE certification regulations. Considered the Gold Standard in organ preservation, it is a sterile, non-pyrogenic and non-toxic solution for the in-vitro flushing and temporary continuous perfusion preservation of the explanted organs.

PumpProtect® is optimized for hypothermic machine perfusion (HMP) of liver and kidney in providing an extracellular-like solution (high sodium, low potassium), mimicking the blood’s natural plasma to keep the blood vessels relaxed, dilated, and safe for continuous fluid flow. The gold standard in organ preservation, allowing for cold ischemic storage times of up to 20+ hours depending on the organ.

PumpProtect® offers transplant specialists a premium hypothermic MPS preservation solution specifically designed to support medical teams from organ procurement through to transplantation.
PumpProtect® is compatible with a wide range of hypothermic machine perfusion systems.

Preparation & Use

PumpProtect® must be stored in liquid form between +2°C and +25°C, protected from sunlight, cooled before use, and never frozen.

Prior to administration PumpProtect® bags should be cooled to between 2°C and 6°C and visually inspected for clarity and colour.

During organ retrieval, PumpProtect® is administered using standard organ preservation protocols to achieve cooling and continuous machine perfusion of organs.

PumpProtect® should be used by qualified healthcare professionals in accordance with transplant centre protocols. Instructions for Use Links Finally, for MPS storage, the organ must be completely immersed in the solution within its storage container, adhering strictly to the protocols of the transplant center. Donor organs must be flushed free of PumpProtect® prior to transplantation in accordance with the transplant center’s protocols.

Carnamedica Store Protect

Clinical Application

PumpProtect® is intended for the flushing and continuous hypothermic machine prefusion (HMP) of organs (kidney and liver) during their storage, transportation, until transplantation, into a recipient, for a period of not more than 24 hours.

Product Specifications

PumpProtect® is a clear to light yellow, sterile, non-pyrogenic solution with an approximate osmolality of 300 mOsm/ kg, potassium concentration of 25 mmol/L and a pH of approximately 7,4 at room temperature.

Composition

Calcium chloride (dihydrate)

0,068 g

0,5 mmol/L

HEPES (free acid)

2,38 g

10 mmol/L

Potassium phosphate (monobasic)

3,4 g

25 mmol/L

Mannitol (USP)

5,4 g

30 mmol/L

Glucose (anhydrous), beta D (+)

1,80 g

10 mmol/L

Sodium gluconate

17,45 g

80 mmol/L

Magnesium gluconate (anhydrous)

1,13 g

5 mmol/L

Ribose, D (-)

0,75 g

5 mmol/L

Pentafraction (HES)

50,0 g

50 g/L

Glutathione (reduced form)

0,92 g

3 mmol/L

Adenine (free base)

0,68 g

5 mmol/L

Hydroxide

qs pH 7.4

Water for injection

qs 1000 mL

Storage Conditions

Shelf Life

18 Months

Temperature

2°C to 25°C, Do not Freeze
To learn more about StoreProtect® or PumpProtect® and discuss integration into your existing transplantation, tissue banking or laboratory program, contact Aurora Bioscience today.

Ordering Information:

Product Code

Description

Presentation

PPRT1000

PumpProtect® Hypothermic Machine Perfusion (HMP) Organ Preservation Solution 1Ltr.

Box / 10 x 1L bags

PPRT2000

PumpProtect® Hypothermic Machine Perfusion (HMP) Organ Preservation Solution 2Ltr.

Box / 5 x 2L bags

SPRT1000

StoreProtect® UW Flushing and Cold Static Storage (CSS) organ preservation solution 1Ltr.

Box / 10 x 1L bags

SPRT2000

StoreProtect® UW Flushing and Cold Static Storage (CSS) organ preservation solution 2Ltr

Box / 5 x 2L bags

Carnamedica Organ Transplant Solutions by Physicians for Physicians

Why Choose Carnamedica?

  1. Gold Standard UW Cold Static Storage Formula – maintains the trusted industry standard UW CSS formulation relied upon by transplant programs worldwide with high-quality reliable availability.
  2. Heightened Safety Through Advanced Manufacturing Process – Produced in an aseptic fill-finish process, proprietary automated aseptic isolator line that eliminates thermal degradation of delicate polymer sugars and oxidation of ingredients caused by autoclaving that other product lines use. Clean fill multi-layer Ethylene Vinyl Acetate (EVA) bags eliminate human contamination factors.
  3. Ready to Use – A sterile, non-pyrogenic solution, supplied in either 1L or 2L bags ready for immediate clinical use, helping to streamline transplant workflows and reduce preparation time especially in aortic flush and high-flow organ perfusion. Designed specifically for your clinical application.
  4. Dedicated Transplant Expertise – Carnamedica focuses specifically on transplantation technologies, providing solutions developed by transplant professionals for transplant professionals.
  5. Local experience with Aurora BioScience – providing local solutions for over 20 years)