PumpProtect®
Exactly formulated to the University of Wisconsin’s UW-MPS (Machine Perfusion Solution) formula, and production technology without autoclaving – chosen by dr Belzer as the only recommended method for production of solutions containing ribose and adenine. It is a sterile, non-pyrogenic and non-toxic solution for the in-vitro flushing and temporary continuous perfusion preservation of the explanted organs. EU CE certified medical device.
PumpProtect® is optimised for hypothermic machine perfusion (HMP) of liver and kidney in providing an extracellular-like solution (high sodium, low potassium), mimicking the blood’s natural plasma to keep the blood vessels relaxed, dilated, and safe for continuous fluid flow.
The solution allows cold ischeamic continuous perfusion for a period of not more than 24 hours.
Produced in an aseptic filling process that eliminates thermal degradation of sugars and oxidation of ingredients caused by autoclaving.
Preparation & Use
PumpProtect® must be stored in liquid form between +2°C and +25°C, protected from sunlight, cooled before use, and never frozen.
Prior to administration PumpProtect® bags should be cooled to approximately 5°C (2°C to 8°C) and visually inspected for leaks, particulate matter, precipitates, contamination, turbidity, clarity and colour.
During organ retrieval, PumpProtect® is administered using standard organ preservation protocols to achieve cooling and continuous machine perfusion of organs.
PumpProtect® should be used by qualified healthcare professionals in accordance with transplant centre protocols. Donor organs must be flushed free of PumpProtect® prior to transplantation in accordance with the transplant centre’s protocols.
Clinical Application
PumpProtect® is intended to be used for continuous hypothermic machine perfusion of organs (kidney and liver) during their storage, transportation, until transplantation into a recipient for a period of not more than 24 hours.
Product Specifications
PumpProtect® is a clear to slightly yellow, sterile, non-pyrogenic, non-toxic solution with an approximate osmolality of 300 mOsm/ kg, potassium concentration of 25 mmol/L, sodium 100 mmol/L, and a pH of approximately 7.4 at room temperature.
| Composition | Amount/1000 mL | Concentration |
| Calcium chloride (dihydrate) | 0.068 g | 0.5 mmol/L |
| HEPES (free acid) | 2.38 g | 10 mmol/L |
| Potassium phosphate (monobasic) | 3.4 g | 25 mmol/L |
| Mannitol (USP) | 5.4 g | 30 mmol/L |
| Glucose (anhydrous), beta D (+) | 1.80 g | 10 mmol/L |
| Sodium gluconate | 17.45 g | 80 mmol/L |
| Magnesium gluconate (anhydrous) | 1.13 g | 5 mmol/L |
| Ribose, D (-) | 0.75 g | 5 mmol/L |
| Pentafraction (HES) | 50.0 g | 50 g/L |
| Glutathione (reduced form) | 0.92 g | 3 mmol/L |
| Adenine (free base) | 0.68 g | 5 mmol/L |
| Sodium Hydroxide | qs pH 7.4 | |
| Water for injection | qs 1000 mL |
| Storage Conditions | |
| Shelf Life | 18 Months |
| Temperature | 2°C to 25°C, Do Not Freeze |
To learn more about StoreProtect® or PumpProtect® and discuss integration into your existing transplantation, tissue banking or laboratory program, contact Aurora Bioscience today.
Ordering Information:
| Product Code | PRODUCT Description | SUPPLY Presentation |
| PPRT | PumpProtect® Machine Perfusion Solution (MPS) for organ preservation 1Ltr. | 1000mL Bags (10 per Box) |
| PPRT2000 | PumpProtect® Machine Perfusion Solution (MPS) for organ preservation 2Ltr. | 2000mL Bags (5 per Box) |
| SPRT | StoreProtect® Cold Storage Solution (CSS) for organ preservation 1Ltr. | 1000mL Bags (10 per Box) |
| SPRT2000 | StoreProtect® Cold Storage Solution (CSS) for organ preservation 2Ltr. | 2000mL Bags (5 per Box) |
Carnamedica Organ Transplant Solutions by Physicians for Physicians
Why Choose Carnamedica?
- UW Cold Storage Solution Formula Free from Heat-Induced Component Degradation – maintains the trusted industry standard UW CSS formulation relied upon by transplant programs worldwide with high-quality reliable availability.
- Heightened Safety Through Advanced Manufacturing Process – The product is manufactured using aseptic filling process that eliminates thermal degradation of sugars and oxidation of ingredients caused by autoclaving. The EVA film container ensures that the medical device remains stable throughout its shelf life.
- Ready to Use – A sterile, non-pyrogenic solution, supplied in either 1L or 2L bags ready for immediate clinical use, helping to streamline transplant workflows and optimise Tx outcomes.
- Dedicated Transplant Expertise – Carnamedica focuses specifically on transplantation technologies, providing solutions developed by transplant professionals for transplant professionals.
- Local experience with Aurora BioScience – providing local solutions for over 20 years.